The Forest
Its enemies are a clan of genetic mutants with beliefs, families and morals who appear almost…
PC / PlayStation / VR
In these games the enemies were once people or animals, changed by a virus, an experiment or something living in the dark. You fight or slip past pale cave dwellers, infected villagers and stitched-together bioweapons. The fear comes from bodies that look almost human and from never knowing what the next one has turned into.
The top 30 of 59 mutant horror games, ranked by player and critic scores
SurvivalThe ForestIts enemies are a clan of genetic mutants with beliefs, families and morals who appear almost human, and worse deformed ones live in the caves
96% on Steam (685,275 reviews) · 15 h or more · Paid · PC, PlayStation, VR
SurvivalWicked SeedThe story turns into a biological nightmare of mutated creatures, which reviewers liken to Parasite Eve's DNA mutation
95% on Steam (1,487 reviews) · about 8 h · Paid · PC
Multiple endingsBioShockIts Splicers are citizens twisted by genetic modification, and you inject plasmids that rewrite your own body.
94% on Steam (32,277 reviews) · 12 h or more · Paid · PC, Xbox
Co-opSpecies: UnknownThe developer's content description mentions mutant monsters among the threats aboard the ship.
94% on Steam (11,609 reviews) · about 25 min · Paid · PC
SurvivalNO-SKINThe friends you fight early on later grow into ghastly, changed forms as you go deeper into the house.
94% on Steam (1,436 reviews) · about 30 min · Paid · PC, PlayStation, Xbox, Switch
PsychologicalRecord of GreypineAnomalies called Derivatives mutate the animals and plants of this alternate early-2000s world
98% on itch.io (328 ratings) · about 2 h · Pay what you want · PC, Mac, Linux
SurvivalResident Evil 3 Nemesis (1999)Steam's feature list warns of mutations stalking the streets: skinless dogs, giant spiders and clawed creatures.
95% on the PlayStation Store (11,720 ratings) · about 6 h · Paid · PC, PlayStation
SurvivalEndoparasiticThe lab is full of horribly mutated monsters, the station's staff turned by the outbreak.
94% on Steam (3,106 reviews) · about 2.5 h · Paid · PC, Mac, Linux, Xbox, Switch
SurvivalResident Evil 2 (1998)The store promises more mutant creatures, among them a skinless thing with an exposed brain and a giant plant
96% on GOG (2,714 ratings) · about 6 h · Paid · PC
EscapeSTASIS: BONE TOTEMMutated creatures wait in the vents and the cutscenes show the lab's monsters.
93% on Steam (2,689 reviews) · 12 h or more · Paid · PC, Mac, PlayStation, Xbox, Switch
Multiple endingsAntarctica 88: Scary GamesSteam describes the enemies as mutated monsters that you fight with the weapons you collect
92% on Google Play (182,456 ratings) · about 1.5 h · Free to play · iPhone, Android, PC, Xbox, Switch
SurvivalDead Space (2008)The infected dead are twisted into Necromorphs that can sprout new limbs when wounded.
92% on Steam (29,363 reviews) · 11 h or more · Paid · PC, Xbox
SurvivalMetro 2033 ReduxThe besieged station-cities fight the mutant horrors that wait outside, and winged mutants hunt you on the surface
92% on Steam (143,484 reviews) · about 9 h · Paid · PC, Mac, Linux, PlayStation, Xbox, Switch
Multiple endingsMetro: Last Light ReduxMutants stalk the catacombs beneath the surface and attack in swarms, and others hunt in the poisoned skies above
91% on Steam (82,615 reviews) · 10 h or more · Paid · PC, Mac, Linux, PlayStation, Xbox, Switch
2D horrorBefore The NightMeat-starved mutants appear from nowhere to roam the streets of the animal world after dark
94% on Steam (458 reviews) · about 5.5 h · Paid · PC, Switch
SurvivalSCP: Fragmented MindsThe first SCP you meet in Chapter One is SCP-3199, a flock of mutated chicken-like creatures.
91% on Steam (1,260 reviews) · Paid · PC
Action horrorSystem ShockMuch of the crew has been mutated by SHODAN, and pale, bloodied mutants rush you in the corridors
90% on Steam (13,113 reviews) · 13 h or more · Paid · PC, PlayStation, Xbox, Switch
SurvivalGround ZeroEvery living thing touched by the impact is mutated: dogs first, then people, then stranger creatures
88% on Steam (759 reviews) · 11 h or more · Paid · PC, PlayStation, Xbox
Multiple endingsBioShock 2Its Splicers are citizens twisted by splicing their genes with ADAM, and you inject plasmids yourself.
89% on Steam (15,009 reviews) · 11 h or more · Paid · PC, Xbox
Body horrorVomitoreumThe fog's infection has turned the land's denizens into wretched mutants you shoot your way through.
91% on Steam (899 reviews) · about 2.5 h · Paid · PC, Linux
SurvivalHeaven Dust 2Besides ordinary zombies there are mutated monsters: the armoured Bone Fiend, the regenerating Blood Fiend and the boomlad
90% on Steam (861 reviews) · 10 h or more · Paid · PC, Switch, PlayStation
SurvivalHeaven DustA hulking mutant with an eye in its chest looms over the zombies in the key art and waits as the boss.
92% on Steam (601 reviews) · about 4 h · Paid · PC, Switch, Xbox, PlayStation
EscapeEvil Nun 2: OriginsMadeline's three mutant chickens, Gummy, Mr. C and a long-necked third, hunt you with her.
88% on Google Play (137,000 ratings) · Free to play · iPhone, Android
Action horrorPathogen-XThe Pathogen-X virus turns the lab's staff into droves of violent mutants that you shoot your way through.
94% on itch.io (181 ratings) · about 30 min · Free · PC
SurvivalSons Of The ForestPale mutants of fused bodies and many limbs wait in the caves, lit only by your torch.
88% on Steam (323,418 reviews) · 11 h or more · Paid · PC
SurvivalCANINEReuben, a mutant dog-human hybrid about eight feet tall, stalks the building
96% on Steam (317 reviews) · about 30 min · Paid · PC, Mac, Switch, PlayStation, Xbox
Action horrorThe Killing AntidoteThe store's synopsis has humans constantly infected and mutated, and some mutants crawl along the ceiling.
88% on Steam (7,958 reviews) · 10 h or more · Paid · PC
SurvivalSystem Shock 2: 25th Anniversary RemasterHybrid mutants, once crew, roam the halls with pipes and shotguns.
88% on Steam (2,304 reviews) · 12 h or more · Paid · PC, PlayStation, Xbox, Switch
Sci-fi horrorRetroSpaceWeird animal and plant hybrids roam the corridors, and your own Mutamods mutate you with side effects
90% on Steam (531 reviews) · 13 h or more · Paid · PC, PlayStation, Xbox
Co-opResident Evil 5A biological agent transforms the local people, and larger bioweapons wait at the end of chapters.
87% on Steam (68,924 reviews) · 12 h or more · Paid · PC, PlayStation, Xbox, Switch
17 games
Its enemies are a clan of genetic mutants with beliefs, families and morals who appear almost…
PC / PlayStation / VR
The developer's content description mentions mutant monsters among the threats aboard the ship.
PC
Its Splicers are citizens twisted by splicing their genes with ADAM, and you inject plasmids…
PC / Xbox
Pale mutants of fused bodies and many limbs wait in the caves, lit only by your torch.
PC
Hybrid mutants, once crew, roam the halls with pipes and shotguns.
PC / PlayStation / Xbox / Switch
A biological agent transforms the local people, and larger bioweapons wait at the end of…
PC / PlayStation / Xbox / Switch
Mutated creatures born of the company's genetic research stalk the halls, each hunting in its…
PC
Mutated creatures break free from their cells, some spawning clones and others moving at super…
PC / Xbox
The Afflicted are joined by the Rotten, whose bones show through their bodies, and the…
PC / PlayStation / Xbox / Switch
The Ooze and the Wall Blister are creatures mutated by the T-Abyss virus.
PC / PlayStation / Xbox / Switch
Done in an hour or so
The developer's content description mentions mutant monsters among the threats aboard the ship.
PC
The friends you fight early on later grow into ghastly, changed forms as you go deeper into the…
PC / PlayStation / Xbox / Switch
Steam describes the enemies as mutated monsters that you fight with the weapons you collect
iPhone / Android / PC / Xbox / Switch
The Pathogen-X virus turns the lab's staff into droves of violent mutants that you shoot your…
PC
Reuben, a mutant dog-human hybrid about eight feet tall, stalks the building
PC / Mac / Switch / PlayStation / Xbox
Zeds are twisted mixes of flesh and machinery, such as the chainsaw-armed Scrake and the…
PC / PlayStation / Xbox
5 games
Anomalies called Derivatives mutate the animals and plants of this alternate early-2000s world
PC / Mac / Linux
Steam describes the enemies as mutated monsters that you fight with the weapons you collect
iPhone / Android / PC / Xbox / Switch
Madeline's three mutant chickens, Gummy, Mr. C and a long-necked third, hunt you with her.
iPhone / Android
The Pathogen-X virus turns the lab's staff into droves of violent mutants that you shoot your…
PC
The maker's own line: a dilapidated research facility full of mystery, mayhem and monstrous…
Browser
Scores are those players and critics give on the stores and sites named; each game's page says where.