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Horror games about human experiments

In these games someone has been testing on people: a company lab under a mansion, a father's basement, a classified study you signed up for, a facility that keeps its captives as specimens. You are often the test subject yourself, or you walk through what the tests left behind. The fear is in the cells, the records and the people who are still running the work.

The top 30 of 78 horror games about human experiments, ranked by player and critic scores

The 30 best, 2026

  1. White Knuckle key art: the title in rough white letters with a clenched white fist on the W, over dark grey concrete PS1White KnuckleThe Nest region is a containment sector holding the creatures that were once subject to experimentation. 98% on Steam (15,667 reviews)11 h or morePaidPC
  2. Resident Evil Requiem art: Grace Ashcroft, with pale, tousled hair and a brown leather jacket, looks sideways on a grey city street SurvivalResident Evil RequiemA blind girl, Emily, is held captive and experimented on, and the villain is a former Umbrella scientist. 96% on Steam (187,672 reviews)12 h or morePaidPC, PlayStation, Xbox, Switch
  3. Mad Father key art: Aya, a black-haired girl with a red bow, cowers as a pale, blood-stained hand reaches for her 2D horrorMad FatherAya's father experiments in his laboratory, and his escaped test subjects fill the house 97% on Steam (6,879 reviews)about 3 hPaidPC, Switch
  4. Unsorted Horror key art: the title in large white letters over a sepia CD-R disc on a black background PsychologicalUnsorted HorrorCarbon Steel is hazardous research in an abandoned facility, and one task is measuring a dose to sedate a huge creature 97% on Steam (3,768 reviews)about 1 hFreePC
  5. SCP – Containment Breach key art: the game's title in scratched, blood-spattered letters over a dark textured background SurvivalSCP – Containment BreachYou play D-9341, a Class D test subject used in the study of SCP-173. 97% on Steam (2,080 reviews)FreePC
  6. INSIDE key art: the boy hides behind a pillar in a dark factory while a machine sweeps the room with a searchlight PsychologicalINSIDEDeeper in, a facility of scientists runs experiments on bodies kept under water. 97% on Steam (76,338 reviews)about 2 hPaidPC, PlayStation, Xbox, Switch, iPhone
  7. Mind the Gap key art: a stern monochrome face with a red blotch beside a pale drawn curly-haired figure, under the red title and the words Chapter 3 is out PsychologicalMind the GapA stranger with a television for a head tells the passengers only that this is an experiment. 98% on itch.io (440 ratings)about 4 hPay what you wantPC, Mac, Linux, Android
  8. Symbiosis key art: a pixel-art woman and a child in a cat-ear beanie holding a bloody knife, among dead trees and pink flowers under a red moon 2D horrorSymbiosisHer notes describe growing a homunculus from mandrake and human tissue, and the maker warns of human experimentation. 96% on itch.io (893 ratings)about 45 minFreeBrowser, PC
  9. Outlast library art: a hulking scarred inmate with a stitched grin and glowing eyes stands in a dark asylum corridor, seen in green night vision SurvivalOutlastMurkoff's secret "research and charity" branch runs the asylum, and the store calls it hell as an experiment you can't survive. 93% on the PlayStation Store (179,484 ratings)about 5 hPaidPC, Mac, Linux, PlayStation, Xbox, Switch
  10. In Sound Mind key art: a man in a hat with a gaping mouth of teeth for a face, a cracked mannequin woman with a cat on her shoulder, a ghostly girl and a lighthouse PsychologicalIn Sound MindThe patients you find were all exposed to the same experimental chemical. 95% on Steam (7,056 reviews)10 h or morePaidPC, PlayStation, Xbox, Switch
  11. Lobotomy Corporation key art: the AI Angela, eyes closed, in a lab coat with long pale hair, on a black background 2D horrorLobotomy CorporationEmployees test each unknown Abnormality with different kinds of work, learning by trial and error what it reacts to. 94% on Steam (58,014 reviews)59 h or morePaidPC
  12. F.E.A.R. key art: the F.E.A.R. logo beside Alma, a pale dark-haired girl, on an orange background Action horrorF.E.A.R.The enemies are Replicas, telepathically controlled clone soldiers, and Perseus Mandate digs into the dark past of Armacham Technology Corporation. 94% on Steam (19,718 reviews)about 8 hPaidPC
  13. Dino Crisis key art: a scaly raptor foot with a raised curved sickle claw on a blood-smeared floor, lit against darkness SurvivalDino CrisisA scientist reported dead three years earlier has secretly resumed his Third Energy experiments on the island. 94% on the PlayStation Store (8,128 ratings)about 6.5 hPaidPC, PlayStation
  14. STASIS: BONE TOTEM key art: a frightened woman in a diving helmet underwater, a toothed orange-lit tentacle coiled around her in the green dark EscapeSTASIS: BONE TOTEMThe lab's experiments and twitching horrors are what the couple uncover as they explore. 93% on Steam (2,689 reviews)12 h or morePaidPC, Mac, PlayStation, Xbox, Switch
  15. Mr. TomatoS key art: a crudely drawn smiling red tomato with half-closed eyes beside the yellow title on a cyan background PsychologicalMr. TomatoSFans who dug through the side program Project UroboroS found that the fruit were people changed by a secret project. 94% on itch.io (757 ratings)about 30 minPay what you wantPC
  16. Resident Evil (1996) key art: a pale zombie with a wound in its forehead and a bloodied shirt turns toward the viewer out of black darkness SurvivalResident Evil (1996)The store describes a biotechnical experiment gone hideously wrong behind the mansion's horrors. 94% on GOG (1,830 ratings)about 6.5 hPaidPC
  17. Resident Evil art: the dim grand hall of the mansion with carved balconies, columns, candelabras and a central staircase SurvivalResident EvilBeneath the grounds lies a secret Umbrella laboratory where experiments were carried out. 92% on Steam (37,103 reviews)11 h or morePaidPC, PlayStation, Xbox, Switch
  18. The Outlast Trials art: three test subjects with night-vision goggles strapped to their faces, one screaming with an arm raised, in a murky olive tint SurvivalThe Outlast TrialsMurkoff conditions its test subjects, called Reagents, for obedience and to turn them into sleeper agents 92% on Steam (120,983 reviews)13 h or morePaidPC, PlayStation, Xbox
  19. Flesh Made Fear key art: a red-tinted face in a surgical mask beside a rotting skull and monsters SurvivalFlesh Made FearA former CIA scientist carries on illegal human and mind-control experiments. 93% on Steam (447 reviews)about 6 hPaidPC, PlayStation
  20. Dad's Monster House key art: grayscale cartoon monsters, a black cat and a giant spider gather before a fence as a car drives past under a full moon Multiple endingsDad's Monster HouseHis father became a mad scientist, and reviewers describe the house as the home of a scientist and his creations 93% on Steam (274 reviews)about 3 hPaidPC, Mac, Xbox, iPhone, Android
  21. Prey key art: Morgan Yu in a red suit and glowing helmet stands beneath a huge black, smoke-like alien shape that holds the Moon and the Talos I station SurvivalPreyMorgan Yu was the key subject of an experiment meant to change humanity, run aboard the station. 91% on Steam (54,912 reviews)16 h or morePaidPC, PlayStation, Xbox
  22. Clea key art: two frightened red-haired children huddle together under a stormy night sky as pale, red-clawed hands reach for them SurvivalCleaMum and Dad have been experimenting on the Chaos Servants, and that is how the monsters got loose 97% on Steam (372 reviews)about 4.5 hPaidPC, Mac, Linux, Switch, PlayStation, Xbox
  23. Quiet is the Eyes key art: a worried researcher in glasses and a lab coat in a blue-lit office, with black splatters and a dripping handprint on the window behind her 2D horrorQuiet is the EyesLab records tell of a classified, highly intelligent specimen and the mysterious experiments the lab conducted. 96% on Steam (225 reviews)about 15 minFreePC
  24. Caput Mortum key art: a man in a white shirt shields his eyes and holds a dagger, ringed by green serpents and winged insects before an alchemical symbol SurvivalCaput MortumThe store warns of experiments on humans; the alchemists tried to make artificial beings. 95% on Steam (379 reviews)about 2.5 hPaidPC, PlayStation, Xbox, Switch
  25. Discover My Body cover: a noisy pixelated face with dark hollow eyes and mouth, staring out of the black inside a red frame Body horrorDiscover My BodyYou are a medical student set to watch and scan a man through each stage of the flowering procedure. 92% on itch.io (626 ratings)about 10 minPay what you wantPC, Mac, Linux
  26. OVERD0SE key art: a pale dark-haired young man with blood on his cheek and hand shows pills on his tongue, beside the handwritten title PsychologicalOVERD0SEThe clues suggest the man treating you may have been experimenting on you long before you remember. 92% on itch.io (554 ratings)about 3 hPay what you wantBrowser, PC, Mac
  27. Lucid Dream key art: an anime-style girl asleep in a wooden bed under a purple blanket, a small glowing-eyed creature beside her face, in blue night light AnimeLucid DreamThe place she is trapped in is where terrible experiments were carried out, and the notes tell of a crime from long ago. 91% on Steam (1,027 reviews)about 45 minFreePC
  28. Tormented Souls key art: a twisted figure stands in a red-lit corridor lined with suits of armour, glowing light behind it SurvivalTormented SoulsThe maker's bestiary says elderly patients were subjected to awful experiments and had their eyes replaced by tuning forks. 90% on Steam (8,283 reviews)12 h or morePaidPC, PlayStation, Xbox, Switch
  29. Human Construction Site cover: a dark-haired figure's red eye seen through a red warning triangle behind greenish glass, with the title in red SurvivalHuman Construction SiteCaptives are kept as specimens in a facility of cells and laboratories, and a computer demands a periodical specimen upload before it opens the gate. 96% on itch.io (180 ratings)about 2.5 hFreeBrowser, PC, Mac
  30. KARMA: The Dark World key art: monochrome portrait of a wet-haired young man in a padded suit with a thick collar and numbered chest plate, lit from above on black PsychologicalKARMA: The Dark WorldYou uncover hints of experiments Leviathan ran on its suspect, and possibly on Daniel, with serious cognitive consequences 91% on Steam (4,617 reviews)about 6 hPaidPC, PlayStation, Xbox

To play with friends

10 games

Short enough for one evening

Done in an hour or so

Free to play

18 games

Every game of the kind

More picks

Scores are those players and critics give on the stores and sites named; each game's page says where.

More kinds of horror

  1. Short horror games621
  2. Psychological horror games530
  3. Horror games with multiple endings417
  4. Horror puzzle games341
  5. Survival horror games259
  6. 2D horror games254
  7. PS1 horror games233
  8. Stealth horror games180
  9. Horror escape games164
  10. Surreal horror games145
  11. Horror visual novels137
  12. Anime horror games132
  13. Haunted house games131
  14. Mystery and detective horror games127
Every genre

Where you play

  1. Steam horror games1009
  2. Epic horror games97
  3. GOG horror games270
  4. itch.io horror games592
  5. PC horror games1337
  6. Mac horror games391
  7. Linux horror games261
  8. PlayStation horror games404
  9. Xbox horror games367
  10. Switch horror games317
  11. Mobile horror games188
  12. VR horror games69
  13. Browser horror games236
  1. Scary games1456
  2. Free horror games561
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